Effects of Paraxanthine Supplementation on eSport Performancre
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Gaming Performance Score
研究概览
简要总结
This study will evaluate the effects of daily paraxanthine supplementation on electronic gaming performance, cognitive function, sleep quality, and autonomic responses in healthy adult gamers. Participants will be enrolled in a randomized, double-blind, placebo-controlled, parallel-group study and assigned to receive either paraxanthine or placebo daily for 6 weeks.
Outcome measures will be assessed at baseline, Week 3, and Week 6 and will include electronic gaming performance, cognitive function, visual analog scale ratings, sleep quality questionnaires, hemodynamic responses, and heart rate variability. The study is designed to determine whether paraxanthine supplementation improves performance and selected physiological and psychological outcomes during prolonged electronic gaming sessions.
详细描述
Electronic gaming has grown substantially in popularity, with increasing interest in strategies that may improve performance, cognitive function, sleep quality, and stress management. Despite this growth, there is limited controlled research evaluating nutritional interventions that may influence gaming-specific performance and associated physiological responses.
Paraxanthine is a primary metabolite of caffeine and has been shown to exhibit physiological effects related to alertness, cognitive performance, and central nervous system activity. However, limited research has evaluated the direct effects of paraxanthine supplementation on performance outcomes in electronic gaming environments.
This study is a randomized, double-blind, placebo-controlled, parallel-group trial designed to examine the effects of paraxanthine supplementation on electronic gaming performance and associated cognitive, psychological, and physiological responses. Participants will be assigned to receive paraxanthine or placebo daily for 6 weeks. All participants and study personnel involved in testing and outcome assessment will remain blinded to group assignment throughout the study.
Following screening and informed consent, eligible participants will complete a familiarization session to practice cognitive testing procedures and become oriented to the gaming environment. Participants will complete testing visits at baseline (Week 0), Week 3, and Week 6. Prior to each visit, participants will replicate their dietary intake for 24 hours, maintain their normal caffeine intake pattern, avoid non-habitual stimulants for 48 hours, limit caffeine intake within 3 hours of testing, and complete a 3-hour fast.
At each visit, participants will undergo assessment of body mass, resting heart rate, and blood pressure, followed by completion of sleep questionnaires, cognitive testing, and visual analog scales. After ingestion of the assigned supplement, participants will complete heart rate variability assessment and then perform two standardized 60-minute gaming sessions. Cognitive outcomes, hemodynamic responses, and subjective measures will be reassessed after each gaming period. Heart rate variability will also be assessed following completion of the gaming session.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
This study will employ a double-blind design in which participants, investigators, and study personnel involved in data collection and outcome assessment are blinded to group assignment. Study supplements will be provided in identical capsules and packaging to ensure blinding. Group assignments will be coded and maintained by an independent party not involved in study procedures or data analysis and will remain concealed until completion of data collection and primary analyses.
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 - 40 years of age
- •Self-reported to be beginners to gaming or have no experience at all
- •Body Mass Index between 18.5 - 29.9 kg/m2
排除标准
- •Outside of age range
- •Is considered a gamer
- •Body mass index is outside of posted inclusion range
- •Noncompliance with protocol
- •Women who are currently pregnant or are actively planning to become pregnant
研究组 & 干预措施
Paraxanthine
Participants assigned to this group will ingest paraxanthine daily for 6 weeks. All participants will complete identical testing procedures at baseline (Week 0), Week 3, and Week 6.
干预措施: Paraxanthine (Dietary Supplement)
Placebo Comparator
Participants assigned to this group will ingest a placebo supplement daily for 6 weeks. All participants will complete identical testing procedures at baseline (Week 0), Week 3, and Week 6.
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Gaming Performance Score
时间窗: Time Frame: Change from baseline (Week 0) to Week 6
Electronic gaming performance will be assessed using standardized gameplay metrics collected during 60- and 120-minute gaming sessions. Primary variables include knock-outs, falls, damage given, damage taken, hit percentage, and peak damage.
Trail Making Test Part A (Completion Time)
时间窗: Time Frame: Change from baseline (Week 0) to Week 6
Cognitive processing speed and visual attention will be assessed using Trail Making Test Part A, including total time to completion.
Trail Making Test Part B (Completion Time)
时间窗: Time Frame: Change from baseline (Week 0) to Week 6
Cognitive processing speed and visual attention will be assessed using Trail Making Test Part B, including total time to completion.
Trail Making Test Part A (Errors)
时间窗: Time Frame: Change from baseline (Week 0) to Week 6
Cognitive processing speed and visual attention will be assessed using Trail Making Test Part A, including total number of errors.
Trail Making Test Part B (Errors)
时间窗: Time Frame: Change from baseline (Week 0) to Week 6
Cognitive processing speed and visual attention will be assessed using Trail Making Test Part B, including total number of errors.
Stroop Color and Word Test Performance
时间窗: Time Frame: Change from baseline (Week 0) to Week 6
Cognitive performance will be assessed using the Stroop Color and Word Test, including response time and accuracy.
Profile of Mood States (POMS) Total Mood Disturbance Score
时间窗: Time Frame: Change from baseline (Week 0) to Week 6
Mood state will be assessed using the Profile of Mood States questionnaire, with calculation of total mood disturbance score.
Pittsburgh Sleep Quality Index (PSQI) Score
时间窗: Time Frame: Change from baseline (Week 0) to Week 6
Sleep quality will be assessed using the Pittsburgh Sleep Quality Index (PSQI) global score.
Heart Rate Variability (HRV)
时间窗: Time Frame: Change from baseline (Week 0) to Week 6
Autonomic function will be assessed using heart rate variability metrics including RMSSD, high-frequency power, low-frequency power, and LF:HF ratio.
次要结局
未报告次要终点