Second Transplantation for Graft Failure
Not Applicable
- Conditions
- Stem Cell Transplant ComplicationsGraft Failure
- Interventions
- Other: second allogeneic stem cell transplantation
- Registration Number
- NCT03717545
- Lead Sponsor
- Peking University People's Hospital
- Brief Summary
Graft failure is a lethal complication after allogeneic stem cell transplantation, which often need a salvage transplantation. However, the current outcome of second transplantation for graft failure is far from satisfactory. We performed a prospective single-arm study to investigate the safety and efficacy of a novel regimen.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- graft failure after first allogeneic stem cell transplantation
- no active infection or GVHD or severe organ dysfunction
- sign written informed consent
Exclusion Criteria
- active infection, GVHD, organ failure
- expected life < 28 days
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description intervention arm second allogeneic stem cell transplantation second allogeneic stem cell transplantation
- Primary Outcome Measures
Name Time Method engraftment 28 days after second transplantation Engraftment of neutrophils was defined as the first of 3 consecutive days when the absolute neutrophil count achieved 500/uL.
- Secondary Outcome Measures
Name Time Method TRM at 28 day 28 days after second transplantation treatment-related mortality(TRM) was defined as death from any cause other than relapse.
Overall survival at 100d day100 after second transplantation Overall survival at 100d
TRM at 100d day 100 after second transplant treatment-related mortality(TRM) was defined as death from any cause other than relapse.
Trial Locations
- Locations (1)
Peking University People's Hospital
🇨🇳Beijing, Beijing, China