Comparison between Dexmedetomidine and Magnesium sulphate as adjuvants to propofol for postoperative recovery in patients undergoing Endoscopic Retrograde Cholangiopancreatography under Monitored Anaesthesia Care A Randomised Comparative Trial

This study will be conducted in the Department of Anaesthesiology in DR S N Medical College and the associated group of hospitals. To ensure inclusion in the study, each patient will be subjected to a detailed pre-anaesthetic evaluation based on detailed history from patients/attenders, thorough physical examination, and pre-anaesthetic airway assessment. Baseline investigations will be done in all the patients to rule out any abnormalities. The purpose and detailed procedure will be explained to the patients. Written informed consent will be taken from all the patients about the procedure. All patients will be kept nil by mouth as per standard guidelines before the scheduled time of surgery.The patient’s NBM status will be confirmed before the scheduled time of surgery. After arrival to the operating room, routine parameters like heart rate, ECG, pulse oximetry and non-invasive blood pressure will be recorded (for the baseline values). The intravenous line will be secured using an 18/20 G IV cannula and Inj. Ringer Lactate will be started slowly.

The randomization will be done on a computer-generated random number chart using block randomization (1:1) and allocation concealment will be done by an opaque, sealed envelope method opened during pre-anesthetic checkup. All patients will be randomly allocated into two groups, Group D (dexmedetomidine and propofol) and Group M (magnesium sulphate and propofol).