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Clinical Trials/NCT06770101
NCT06770101
Recruiting
Not Applicable

Suicide Assessment and Feasible Evidence-based Treatments for Youth Living With HIV in Lilongwe: SAFETY Planning Pilot Trial

University of Pennsylvania4 sites in 1 country60 target enrollmentJune 14, 2025
ConditionsHIVSuicide

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
HIV
Sponsor
University of Pennsylvania
Enrollment
60
Locations
4
Primary Endpoint
Proportion of sessions meeting fidelity threshold (intervention fidelity)
Status
Recruiting
Last Updated
6 months ago

Overview

Brief Summary

The overall aim of this study is to determine the feasibility, fidelity, acceptability, and preliminary effectiveness of the Friendship Bench +Safety Planning intervention in reducing suicidal ideation and behaviors (SIBs) and improving HIV engagement amongst adolescents living with HIV (ALWH) when compared to augmented usual care.

Detailed Description

This project aims to evaluate the feasibility, acceptability, fidelity, and preliminary effectiveness of the enhanced Friendship Bench+Safety Planning (FB+SP) intervention model. We will enroll 60 depressed ALWH who report suicidality from four facilities in Lilongwe, Malawi, and randomize them 1:1 to the enhanced FB+SP model or augmented usual care. This pilot trial is a step toward our long-term goal of generating and implementing an evidence-based model to prevent suicide in Malawi amongst ALWH by enhancing the capacity of the health system to identify suicidality and provide evidence-based care. Information gathered in this proposal will be used to develop a subsequent randomized control trial.

Registry
clinicaltrials.gov
Start Date
June 14, 2025
End Date
September 1, 2026
Last Updated
6 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Melissa Stockton

Assistant Professor of Psychiatry

University of Pennsylvania

Eligibility Criteria

Inclusion Criteria

  • Age 13-19
  • Diagnosed with HIV
  • Report current or historical suicidal ideation and behaviors (SIBs) on question 9 of the Patient Health Questionnaire modified for adolescents (PHQ-9-A) and the Ask Suicide-Screening questionnaire (ASQ)
  • Living in the clinic's catchment area with intention to remain for more than 1 year
  • Willing to provide consent (age 18+ or 16-17 years old and married and thereby considered emancipated minors per Malawi law) or assent with parental consent (age 13-17).

Exclusion Criteria

  • Refuse to participate
  • Refuse to be audio-taped for in-depth interviews

Outcomes

Primary Outcomes

Proportion of sessions meeting fidelity threshold (intervention fidelity)

Time Frame: 6 months

The proportion of sessions meeting or exceeding expectations for at least 80% of the total number of fidelity checklist items assessed per session during random monitoring sessions out of all sessions monitored.

Study retention (study feasibility)

Time Frame: Through study completion- 6 months

This outcome measure of feasibility will be measured as the ability to retain ALWH in the pilot trial. Feasibility will be evaluated by measuring the number of participants retained in the study (number of patients enrolled at baseline who are still enrolled in the trial) through study completion.

Recruitment rate (Intervention feasibility)

Time Frame: Baseline

This outcome measure of feasibility will be measured as the ability to successfully enroll ALWH in the pilot trial. Feasibility will be evaluated by measuring the recruitment rate (number of patients approached in order to accrue the final sample).

Overall satisfaction with the intervention among participants (intervention acceptability)

Time Frame: 6 months

The proportion of participants who found the intervention acceptable and helpful among all participants who received the intervention.

Secondary Outcomes

  • Prevalence of suicidal ideation and behaviors(6 months)
  • Prevalence of suicide risk(6 months)
  • Prevalence of depressive symptoms(6 months)

Study Sites (4)

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