Depression and Anxiety Reduction Treatment for Suicide

Not Applicable

Completed

• Conditions: Depression; Anxiety; Suicide

• Registration Number: NCT01941862
• Lead Sponsor: Florida State University

Brief Summary

The purpose of this study is to test the effectiveness and usability of multiple computer-based treatments for mood and anxiety relevant risk factors. The target of the treatment is related to cognitive stress, which has been shown to be associated with a variety of negative mental health outcomes such as Post-Traumatic Stress Disorder, suicidal ideation, and substance use disorders.

Detailed Description

DARTS is a newly developed computerized treatment targeting specific risk factors associated with suicide, mood, and anxiety symptoms. Eligible individuals will be randomized to one of several conditions. In all conditions, participants will complete various self-report questionnaires and a neurophysiology assessment that involves an EEG. Some participants will also be asked to complete four additional EEG assessments. In addition, all participants will be asked to complete a 1, 3, and 6-month follow-up appointment.

Study Timeline

• Study First Submitted: 2013-07-20
• Study First Submitted QC: 2013-09-10
• Study First Posted: 2013-09-13
• Study Start: 2013-11
• Primary Completion: 2017-09
• Study Completion: 2017-09
• Status Verified: 2018-06
• Last Update Submitted: 2018-06-18
• Last Update Posted: 2018-06-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• At or above community sample mean on ASI-3
• At or above community sample mean on INQ-R
• English speakers
• 18 years of age or older

Exclusion Criteria

• Significant medical illness
• Current substance dependence
• Current or past psychotic-spectrum disorders
• Uncontrolled bipolar disorder
• Serious suicidal intent that warranted immediate treatment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Interpersonal Needs Questionnaire (INQ)	Month 6 follow-up	The INQ is a 15-item self-report measure of the constructs of thwarted belongingness and perceived burdensomeness as defined by the Interpersonal Theory of Suicide. Van Orden et al. report high internal consistency coefficients for the thwarted belongingness (α=.85) and perceived burdensomeness subscales (α=.89). In support of construct validity, both subscales were found to prospectively predict suicidal ideation.

Secondary Outcome Measures

Name	Time	Method
Anxiety Sensitivity Index-3 (ASI-3)	Month 6 follow-up	The ASI-3 is an 18-item self-report measure of anxiety sensitivity (AS). This scale was developed to provide a more stable measure of the three most widely recognized AS subfactors (cognitive, social and physical concerns) than the original ASI provides. Each subfactor is represented by six items. The measure has shown good psychometric properties.

Trial Locations

Locations (1)

Florida State University; 🇺🇸 Tallahassee, Florida, United States