Recovery After Medical or Surgical Treatment
- Conditions
- Cognitive Deficit
- Registration Number
- NCT03286439
- Lead Sponsor
- Zealand University Hospital
- Brief Summary
This study aims to investigate the in-hospital care as well as the cognitive status, quality of life, physical function and risk of anxiety and depression, sleep disorders and drug use in a Danish cohort of both medical and surgical patients with acute critical illness without admittance to ICU (Intensive Care Unit) treatment, at three and twelve months after hospital discharge.
- Detailed Description
A stay at the ICU (intensive Care Unit) is related to life-threatening conditions and often displays a major impact on both physical and mental resources of the patients. Studies show that a great part of ICU patients have impairments of both physical and psychological kinds, some long-lasting. This condition is termed the "post intensive care syndrome" (PICS) and describes a wide range of symptoms as fatigue, depression, anxiety, memory loss along with both cognitive and physical impairments. Rehabilitative efforts are, thus, needed, and it has been suggested that ideally, rehabilitation should begin at the time of admission to the hospital and continue for a long time, possibly years, after the patient has been discharged. Regarding long term cognitive function of the ICU survivors in particular, recent studies have demonstrated severe impairment at the level of light Alzheimer's disease. In all of these studies, the reference group is the normal population, and it is a general problem that the cognitive and physical function of ICU patients before critical illness is unknown. There has recently been a norwegian study that included a reference group of surgical patients undergoing major surgery. The surgical group was older and more severely ill than the ICU group and was found to have a much worse cognitive function. Moreover, the cognitive function of the critically ill patients was not very far from the normal reference population due to selection.
To determine to which degree the impairments can be attributed to ICU-admission, the investigators need to look at a hospitalised and representative, non-ICU population, which is what will be done in the study. The investigators will therefore include patients that have been admitted to surgical or medical department acute without admittance to the ICU and contact these patients 3 and 12 months after admission. Where there will be performed different tests in order to evaluate the the cognitive status, quality of life, physical function and risk of anxiety and depression, sleep disorders and drug use.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 101
-
Patients > 18 years of age
-
Admitted to surgical or medical department > 3 days
-
Admitted with one of the following diagnoses:
- Pneumonia
- Heart failure
- Pulmonary embolism
- Acute myocardial infarction
- Pyelonephritis
- Patients undergoing non-elective open or laparoscopic abdominal surgery (not including elective procedures, diseases of the appendix, diseases of the gallbladder, liver, spleen, kidney, pancreas and emergency hernia surgery without bowel resection)
- Permanently incompetent patients not able to consent
- Not able to speak and understand Danish
- Discharged from the hospital for terminal care
- Patients transferred to another hospital during the stay
- Patients living outside the Region of Zealand
- Patients admitted under duress or actively psychotic
- Patients that are blind or severely visually impaired.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive function 3 months after discharge Cognitive Function measured by The Repeatable Battery for The Assesment of Neuropsychological Status (RBANS)
- Secondary Outcome Measures
Name Time Method Information processing speed 12 months after discharge This will be investigated by filling out the Trail Making Test Part A
Cognitive function after one year 12 months after discharge Cognitive function measured with The Repeatable Battery for the Assessments of Neuropsychological Status (RBANS) evaluation at 12 months after discharge from hospital
Rehabilitation after 3 months 3 months after discharge This will be investigated by filling out a checklist of community support and contact to health care system at 3 month follow up
Self-reported health related quality of life 12 months after discharge This will be investigated by filling out a questionnaire named SF 36, Short Form Health Survey.
Objective assessment of physical function 12 months after discharge This will be investigated by filling out a checklist called CPAx, The Chelsea Critical Care Physical Assessment Tool
Mortality 90 days after discharge The mortality of the patients within 90 days after hospital discharge.
Consumption of opioids 90 days after discharge Percentage of patients with a daily consumption of opioids at hospital admission and 90 days after discharge
Consumption of statins days after discharge 90 days after discharge Percentage of patients with a daily consumption of statins at hospital admission and at 90 days after discharge
Consumption of anti-depressants 90 days after discharge Percentage of patients with a daily consumption of anti-depressants at hospital admission and at 90 days after discharge
Sleepiness 12 months after discharge This will be investigated by filling out Epworth Sleepiness Scale
Insomnia 12 months after discharge This will be investigated by filling out Insomnia Severity Index
Sleep Quality 12 months after discharge This will be investigated by filling out Pittsburgh Sleep Quality Index
Executive function 12 months after discharge This will be investigated by filling out the Trail Making Test Part B
Rehabilitation after 12 months 12 months This will be investigated by filling out a checklist of Community support and contact to health care system at 3 month follow up
Consumption of sleep medication 12 months after discharge Percentage of patients with a daily consumption of sleep medication at hospital admission and 90 days after discharge
Trial Locations
- Locations (1)
Zealand University Hospital
🇩🇰Køge, Denmark