Duration of therapy of anti-seizures medication for Acute Symptomatic Seizure in Children with Acute Encephalitis syndrome
Not Applicable
- Conditions
- Health Condition 1: null- Children with Acute Symptomatic Seizure in Children with Acute Encephalitis syndrome
- Registration Number
- CTRI/2017/06/008783
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Children with acute encephalitis syndrome with acute symptomatic seizures on single anti-epileptic drug will be enrolled in Out patient clinic at 4 week of illness
Exclusion Criteria
1.Children with chronic meningitis, brain abscess, intracranial Space occupying lesion
2.Children with prior history of seizures, prior focal neurological deficit or abnormal development prior to development of seizures
3.HIV, Chronic Liver disease, Chronic Kidney disease, acute hepatic encephalopathy
4.Children on two or more than 2 anti-epileptic drug, severely affected children (Pediatric Cerebral Performance Category Scale (PCPC) Score, Pediatric Overall Performance Category Scale with category score of 5)
5.Refusal of consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Seizure relapse rate (proportion) after stopping anti-epileptic drugs in children with acute symptomatic seizure in the two treatment groups after 6-months of follow upTimepoint: 6 months
- Secondary Outcome Measures
Name Time Method 1.Correlation of EEG findings at time of stoppage of AED with seizure recurrence <br/ ><br>2.Factors associated with seizure recurrence in the two groupsTimepoint: 6 months;Seizure relapse rate (proportion) after stopping anti-epileptic drugs after 12, 18 and 24-months of follow upTimepoint: 12-months, 18 months and 24 months