HIV-1 evolution after transmission - A cohort study to identify evolution of recently transmitted HIV-1
- Conditions
- human immunodeficiency virus type110047438
- Registration Number
- NL-OMON32993
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
* HIV-1 infected partner(s) who are assumed to be the source of HIV-1 transmission (donor) of patients who present with primary HIV-1 infection at the *Primo-SHM* study (recipient) in the AMC (MEC 03/059).
* At least 18 years of age
Exclusion Criteria
None
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Sequence of the viral genome that is present in the HIV-1 donor as close as<br /><br>possible to the time of HIV-1 transmission.<br /><br>* Virus diversity (quasispecies) in the donor-recipient pairs half a year after<br /><br>HIV-1 transmission.<br /><br>* HLA type of donor-recipient pairs, availability of replication competent<br /><br>(pseudo)viruses from donor and recipient.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The relation between viral sequence dynamics and:<br /><br>* The HLA type of donor and recipient<br /><br>* The autologous neutralization profile<br /><br>* Host CTL responses<br /><br>* Viral fitness</p><br>