HIV-1 evolution after transmission. A cohort study to identify evolution of recently transmitted HIV-1 infection.
Recruiting
- Conditions
- primary HIV-1 infectionHIV-1 evolutionviral fitnessHuman Leukocyte antigen (HLA)
- Registration Number
- NL-OMON26446
- Lead Sponsor
- Academic Medical Center (AMC)Investigator driven study, no industrial study
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
1. HIV-1 infected partners who are assumed to be the source of HIV-1 transmission (donor) of patients who present with primary HIV-1 infection at the ‘Primo-SHM’ study (recipient) in the AMC;
2. At least 18 years of age.
Exclusion Criteria
N/A
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Sequence of the viral genome that is present in the HIV-1 donor as close as possible to the time of HIV-1 transmission;<br /><br>2. Virus diversity in the donor-recipient pairs half a year after HIV-1 transmission;<br /><br>3. HLA type of donor-recipient pairs, availability of replication competent (pseudo)viruses from donor and recipient.<br>
- Secondary Outcome Measures
Name Time Method The relation between viral sequence dynamics and:<br /><br>1. The HLA type of donor and recipient;<br /><br>2. The autologous neutralization profile;<br /><br>3. Host CTL responses;<br /><br>4. Viral fitness.<br>