asal Intermittent Positive Pressure Ventilation in Preterm Infants

Completed

• Conditions: Asynchrony of spontaneous breathing and respiratory support; diaphragm activity; 10028971

• Registration Number: NL-OMON43658
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Born at less than 32 weeks of gestational age
- Receiving nIPPV to treat apnea of prematurity
- Written parental informed consent

Exclusion Criteria

- Major congenital anomalies
- Clinical instability requiring frequent interventions by the nursing staff, that may interfere with the measurement
-The attending physician considers the infant to be too vulnerable to participate in the study

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Percentage of synchronicity of ventilator flow cycles and spontaneous breaths<br /><br>of the infant detected by transcutaneous electromyography of the diaphragm<br /><br>(dEMG).<br /><br>Asynchrony index: defined as asynchronous (not- or insufficiently synchronous)<br /><br>breaths divided by all breaths.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>dEMG amplitude variations and volume changes measured with respiratory<br /><br>inductance plethysmography between synchronous and asynchronous breaths. </p><br>