Ventilation Effects of Two-Phase Pressure compared to conventional ventilation in patients hospitalized in the ICU with community-acquired pneumonia
Not Applicable
- Conditions
- Bacterial pneumoniaC01.252.620
- Registration Number
- RBR-62wfjg
- Lead Sponsor
- Hospital Pró Cardíaco
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Signs and symptoms of pneumonia according to current guidelines; Age greater than 18 years;Being on invasive mechanical ventilation for up to 24 hours;Free and informed consent form obtained from the family
Exclusion Criteria
Transplantation (Organ and / or bone marrow);HIV positive;Immunosuppressive treatment (Corticosteroid);Tuberculosis; Hospitalization in other ICUs or emergency department in the last 14 days; Pregnancy; morbid obesity;severe liver disease;Pneumothorax;Clinical decision on palliative care;Estimated duration of mechanical ventilation less 48 hours;Neoplasms and neurological diseases
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Increase in the number of free days of mechanical ventilation within a 28-day interval from entry into mechanical ventilation, as measured by daily visits while the patient is hospitalized.
- Secondary Outcome Measures
Name Time Method Increase survival by 28 days, measured every day through daily visits while the patient is hospitalized.;Increase or decrease of days of ICU stay measured through daily visits while the patient is hospitalized.;Increase or decrease of days of hospital stay measured by daily visits while the patient is hospitalized.;Increased or decreased inflammation markers, interleukins (IL) -8, IL-6, IL-1beta, C-reactive protein, pro-calcitonin, pro-endothelin observed on blood collection on days 1, 3, 7 and 28 through the Bradford method.;Increased or decreased epithelial injury markers sRAGE, SP-A, SP-D, Club Cell protein-16 in blood collection on days 1, 3, 7 and 28 through the Bradford method.