Prevention of West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH)
- Conditions
- West Syndrome
- Interventions
- Drug: adrenocorticotropin hormone
- Registration Number
- NCT01367964
- Brief Summary
West syndrome (WS) is a specific type of epilepsy (or seizure disorder) that has three features: infantile spasms (type of seizure), loss of milestones, and a specific pattern on electroencephalogram (EEG or brain wave test) called hypsarhythmia. The purpose of this study is to detect pre-hypsarhythmia in infants at high-risk for WS and determine whether treatment with ACTH will prevent WS.
- Detailed Description
Hypothesis: Preemptive ACTH will halt the evolution of hypsarhythmia and improve the EEG patterns in infants with pre-hypsarhythmic EEG.
Aim. To determine whether a low dose ACTH improves EEG, we will repeat EEG one month after a 2 week course of daily ACTH.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 28
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description ACTH treatment adrenocorticotropin hormone Infants with a Type 3 EEG (pre-hypsarhythmia) will be treated with ACTH for 2 weeks.
- Primary Outcome Measures
Name Time Method Evidence for improvement in the EEG one month following initiation of the 2 week course of low-dose ACTH. 1 month If pre-hypsarhythmia (Type 3) is detected, ACTH treatment is given for 2 weeks and an EEG is performed one month later. Primary outcome is improvement in EEG (as defined by assigned type).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ann & Robert H. Lurie Children's Hospital of Chicago
🇺🇸Chicago, Illinois, United States