Procalcitonin as a Marker for the Length of Antibiotic Treatment in Peritonitis and Intra-abdominal Infections

Completed

• Conditions: Secondary or Tertiary Peritonitis

• Registration Number: NCT01155739
• Lead Sponsor: University of Lausanne Hospitals

Brief Summary

Procalcitonin level used for determining length of antibiotic treatment in peritonitis and intra-abdominal infections. Hypothesis is that length of antibiotic use can be shortened by this method.

Detailed Description

Prospective randomized trial

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-07-23
• Study First Submitted QC: 2010-07-01
• Study First Posted: 2010-07-02
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-18
• Last Update Posted: 2014-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 162

Inclusion Criteria

• More than 18 yo
• Patient requiring surgery for peritonitis or intra-abdominal infection following: perforation, necrosis, previous operation...
• Mannheim Peritonitis score > 14
• SIRS present
• Probability of survival > 72h
• Informed consent by patient/relatives

Exclusion Criteria

• No SIRS
• Long date corticoid treatment
• Immunosuppression
• Thyroid medullary carcinoma
• Anaphylactic shock
• Acute hepatic deficiency

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
antibiotic treatment length, hospitalisation length without antibiotic, infection recurrence, antibiotic cost	at one month and during hospital stay

Trial Locations

Locations (1)

University Hospital of Lausanne; 🇨🇭 Lausanne, Switzerland