Effect of Prucalopride on esophagus in healthy volunteers.
Completed
- Conditions
- Gastroesophageal reflux disease (GERD)Functional dyspepsiaDelayed Gastric emptyingHeartburnGastro oesophagale reflux zikete (GORZ)Functionele dyspepsieVertraagde maagontledigingZuurbranden
- Registration Number
- NL-OMON24265
- Lead Sponsor
- AMC afd. MDL/Motiliteit
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Written informed consent;
2. Minimum age 18 years;
Exclusion Criteria
1. Surgery of the GI tract other than appendectomy or cholecystectomy;
2. Motility disorders of the GI tract leading to delayed gastric emptying or altered intestinal motility;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of esophageal reflux episodes during the 24-hr study.
- Secondary Outcome Measures
Name Time Method 1. Gastric emptying rate;<br /><br>2. Esophageal contraction amplitudes;<br /><br>3. LES resting pressure;<br /><br>4. Esophageal acid exposure time;<br /><br>5. Number of TLESRs.