Detection of vascular endothelial function post-COVID-19 with carotid artery reactivity testing.

Completed

• Conditions: Endothelial dysfunction; vascular damage; 10047438; 10047079

• Registration Number: NL-OMON49993
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-03-22
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

- Confirmed severe acute respiratory syndrome corona virus 2 (SARS-CoV2)
infection by polymerase chain reaction on nasopharyngeal swab, sputum or
bronchoalveolar lavage.
- 6 to 20 weeks after resolution of COVID-19 related symptoms
- >= 16 years old

Exclusion Criteria

- Recent (<3 months) angina pectoris, myocardial infarction, stroke, or heart
failure
- Raynaud syndrome, scleroderma or complex regional pain syndrome on upper
extremity or presence of arteriovenous fistula or open wounds on both upper
extremities.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Endothelial dysfunction as determined by carotid artery reactivity (CAR) test </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Major adverse cardiovascular events (MACE) within one year post-COVID-19 is an<br /><br>exploratory endpoint. In this study, MACE include non-fatal myocardial<br /><br>infarction, non-fatal ischemic stroke, acute limb ischemia, need for<br /><br>revascularization, amputation and cardiovascular death.</p><br>