Measurement of the intactness of the thin membrane lining the blood vessels in patients with Guillain Barre Syndrome after plasmapheresis.
Not Applicable
- Conditions
- Health Condition 1: G09- Sequelae of inflammatory diseasesof central nervous system
- Registration Number
- CTRI/2023/05/053067
- Lead Sponsor
- Science and Engineering Research Board( Core Research Grant)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All patients
(i) Diagnosed to have Guillain Barre syndrome based on the National Institute of Neurological Disorders and Stroke (NINDS) criteria and Brighton level of certainty one or two.
(ii)Undergoing a minimum of 5 cycles of Therapeutic plasma exchange will be recruited under 2 groups.
Group A: Patients with Guillain Barre syndrome requiring mechanical ventilation and TPE
Group B: Patients with Guillain Barre syndrome requiring TPE, and not requiring mechanical ventilation and ICU care
Exclusion Criteria
Age less than 18 and more than 65 years
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessment of endothelial glycocalyx disruption in patients with Guillain Barre Syndrome undergoing therapeutic plasma exchange therapy.Timepoint: At baseline, after 1st cycle of TPE, after 5th cycle of TPE and at 72 hours after final TPE
- Secondary Outcome Measures
Name Time Method 1. Clinical methods of endothelial activation can be regularly implemented in routine practice before deciding on to TPE therapy. <br/ ><br>2. Replacement fluid during TPE can be standardised <br/ ><br>3. Based on the extent of endothelial disruption appropriate treatment therapy with either TPE or Immunoglobilin therapy can be chosen in critically ill patients admitted at ICU requiring mechanical ventilation.Timepoint: At baseline, after 1st cycle of TPE, after 5th cycle of TPE and at 72 hours after final TPE