Assessment of endothelial dysfunction and premature atherosclerosis in patients with recent onset Rheumatoid Arthritis, a longitudinal study
- Conditions
- gewrichtsaandoeningenrheumatoid arthritis10003216
- Registration Number
- NL-OMON33873
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
fulfill the ACR criteria for RA
symptoms< 1 year
age >18 years
not previously received disease modifying antirheumatic drugs.
Exclusion Criteria
pregnancy
diabetes
renal impairment( eGFR>60ml/min)
recent surgery
myocardial infarction or sepsis in the last three months
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>-Small artery elasticity<br /><br>-Intima media thickness<br /><br>-Advanced glycation end products in de huid</p><br>
- Secondary Outcome Measures
Name Time Method <p>- soluble AGE receptor( s-RAGE)<br /><br>- endothelial activation markers such as VCAM, vWF, trombomoduline</p><br>