The incidence of endothelial dysfunction and atherogenesis in hemophilia patients with obesity: the Idaho-study

• Conditions: hemofilie, atherosclerose, endotheeldysfunctie, obesitas; bleeders' disease; cardiovascular disease; 10003216

• Registration Number: NL-OMON31530
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 160

Inclusion Criteria

Haemophilia A patients (obese or normal weight)
All haemophilia patients are male
All subject are 18 years or older

Exclusion Criteria

pre-existing cardio-vascular disease

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Endothelial function and degree of atherosclerosis will be compared in the four<br /><br>groups. The degree of inflammation, platelet aggregation, fibrin formation, and<br /><br>fibrinolysis will also be assessed in the four different groups. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>We will also investigate the amount of bleeding complications and analyse the<br /><br>influence of obesity on this outcome. </p><br>