Influence of everolimus on atherosclerosis in RA.
Recruiting
- Conditions
- Rheumatoid arthritis, endothelial activation, endothelial dysfunction, intima media thickness, cardio-vascular disease, everolimus
- Registration Number
- NL-OMON28147
- Lead Sponsor
- ovartisUMC Groningen
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
1. Fulfill the American College of Rheumatology criteria for RA;
2. DAS-28 score>3,2;
Exclusion Criteria
1. Pregnancy or breastfeeding status;
2. Diabetes mellitus (fasting blood glucose =/> 7.0 mmol/L);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Endothelial activation as measured by von Willebrand factor, soluble vascular adhesion molecule, thrombomodulin;<br /><br>2. Endothelial dysfunction as measured by small artery elasticity;<br /><br>3. Premature atherosclerosis as measured by intima media thickness.
- Secondary Outcome Measures
Name Time Method 1. Effect of everolimus on RA;<br /><br>2. Drop-out due to side effects of everolimus.