ISRCTN40090372
Active, not recruiting
未知
A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis
ewcastle upon Tyne Hospitals NHS Foundation Trust0 sites2,244 target enrollmentDecember 12, 2023
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Sepsis
- Sponsor
- ewcastle upon Tyne Hospitals NHS Foundation Trust
- Enrollment
- 2244
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Adult patients, age \>\=18 years, treated within a critical care setting (ICU or HDU) for suspected or confirmed sepsis due to either community\- or hospital\-acquired infections.
- •2\. Evidence of new or worsening acute organ dysfunction resulting from suspected or confirmed infection (e.g. the treatment or monitoring of an organ dysfunction).
- •3\. Antibiotics initiated for suspected or confirmed sepsis and able to be randomised within 4 days of the initiation of this course of antibiotics
- •Process evaluation:
- •Clinical staff involved in everyday prescribing and/or managing of antibiotics within critical care.
Exclusion Criteria
- •1\. Comorbidity with immunosuppression (e.g. Chemotherapy, maintenance steroids equivalent to \> 10mg/day of prednisolone, post\-transplantation)
- •2\. Blood neutrophil count less than 0\.5 x 10^9/L secondary to a pre\-existing comorbidity
- •3\. Infection source where usual practice involves more than 14 days of antibiotics (e.g. undrainable abscess, endocarditis, Staphylococcus aureus bacteraemia, osteomyelitis)
- •4\. Receiving end\-of\-life care
- •5\. Life\-sustaining treatment expected to be withdrawn within the next 24 hours.
- •6\. The clinician responsible for the patient’s care is unable to adhere to the intervention.
Outcomes
Primary Outcomes
Not specified
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