ISRCTN40090372进行中（未招募）Unknown
A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis
ewcastle upon Tyne Hospitals NHS Foundation Trust0 个研究点目标入组 2,244 人开始时间: 2023年12月12日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 2,244
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Adult patients, age >=18 years, treated within a critical care setting (ICU or HDU) for suspected or confirmed sepsis due to either community- or hospital-acquired infections.
- •2. Evidence of new or worsening acute organ dysfunction resulting from suspected or confirmed infection (e.g. the treatment or monitoring of an organ dysfunction).
- •3. Antibiotics initiated for suspected or confirmed sepsis and able to be randomised within 4 days of the initiation of this course of antibiotics
- •Process evaluation:
- •Clinical staff involved in everyday prescribing and/or managing of antibiotics within critical care.
排除标准
- •1. Comorbidity with immunosuppression (e.g. Chemotherapy, maintenance steroids equivalent to > 10mg/day of prednisolone, post-transplantation)
- •2. Blood neutrophil count less than 0.5 x 10^9/L secondary to a pre-existing comorbidity
- •3. Infection source where usual practice involves more than 14 days of antibiotics (e.g. undrainable abscess, endocarditis, Staphylococcus aureus bacteraemia, osteomyelitis)
- •4. Receiving end-of-life care
- •5. Life-sustaining treatment expected to be withdrawn within the next 24 hours.
- •6. The clinician responsible for the patient’s care is unable to adhere to the intervention.
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