NCT02001311Unknown1 期
Effect of Chlorhexidine Gel on Bacterial Count and Orthodontic Brackets During Fixed Orthodontic Treatment; In-vivo & In-vitro Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 入组人数
- 20
- 主要终点
- mutants streptococcus count
研究概览
简要总结
This study investigates the benefit of using chlorhexidine gel as an antimicrobial agent in orthodontic patient to reduce caries risk and the possible consequential effect of this use on the orthodontic brackets used for the treatment.
The investigators hypothesis is that chlorhexidine gel use can reduce caries risk in orthodontic patients with out causing damage to the bonded ceramic or metal orthodontic brackets.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients' age range from 18-30 years.
- •Fixed orthodontic treatment.
- •All the patients are at the end of leveling and alignment stage.
- •Initial bacterial count indicates high caries risk.
- •All patients will be given good oral hygiene instruction at the first visit.
- •The subjects had not taken antibiotics for at least 6 weeks before saliva sampling or during the experimental period.
- •All subjects used a fluoride dentifrice twice a day.
排除标准
- •Patients' age more or less then the age range specified.
- •Removable orthodontic treatment.
- •Patients at early stages of leveling and alignment.
- •Initial bacterial count indicates low caries risk.
- •Subjects that have taken antibiotics for at least 6 weeks before saliva sampling.
研究组 & 干预措施
chlorhexidine gel
Experimental
anti microbial agent that prevents the formation of plaque and reduces caries risk
干预措施: Chlorhexidine gluconate (Drug)
结局指标
主要结局
mutants streptococcus count
时间窗: 48 hours
measures the change in bacterial count before and after application of the gel
次要结局
- friction(2 minutes)
研究者
Dr. Samar Al-Bazi
Doctor
King Abdulaziz University
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