NCT02546037CompletedNot Applicable
Pilot Study to Determine the Effect of Different Dialyzer Membranes on Clotting During Haemodiafiltration Treatments in Patients With Chronic Kidney Disease
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University College, London
- Enrollment
- 10
- Primary Endpoint
- convective volume exchanged
Study Overview
Brief Summary
Primary Objective:
The purpose of this study is to measure the amount of convection achieved with two different haemodiafilters designed for haemodiafiltration and clotting during haemodiafiltration treatment.
Detailed Description
This is a prospective observational cohort pilot study of patients under the care of the Royal Free Hospital with chronic kidney disease who have been established on regular thrice weekly haemodiafiltration treatments in a dialysis centre. Information on the study will be disseminated to the Royal Free consultant nephrologists at the dialysis centre with primary responsibility for the individual patient.
Study Design
- Study Type
- Observational
- Observational Model
- Case Crossover
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients age 18 years and older up to 80 years
- •Under the care of the Royal Free Hospital with chronic kidney disease and established on regular thrice weekly haemodiafiltration.
- •Able to provide written informed consent obtained
Exclusion Criteria
- •Patients scheduled for a kidney transplant
- •Patients taking concomitant systemic anticoagulants
- •Patients with known prothrombotic or bleeding disorders
- •Patients with abnormal platelet counts
- •Patients unable to provide written informed consent
- •Patients not fulfilling inclusion criteria
Outcomes
Primary Outcomes
convective volume exchanged
Time Frame: day 1
volume of convective exchange achieved during the HDF session
Secondary Outcomes
- visual coagulation(day 1)
- platelet and coagulation pathway activation(day 1)
- small and middle sized solute clearances(day 1)
Investigators
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