Elderly patients who undergo any major abdominal surgery under general anesthesia will be given Dexmedetomidine in two different doses or plain normal saline,and any changes in memory,recall, language etc will be compared between preoperative and postoperative states

Phase 4

• Conditions: Health Condition 1: O- Medical and Surgical

• Registration Number: CTRI/2024/08/072290
• Lead Sponsor: Rajendra Institute of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

a. Patients belonging to ASA grade I and II.

b. Patients give informed and written consent for surgery.

c. Patients aged 60 years or more.

d.Patients undergoing elective abdominal surgeries lasting for 2 or more hours but not more than 4 hours under General Anesthesia.

Exclusion Criteria

Patients belonging to ASA grade III & IV, Patients who refuse consent, Patients with pre existing diagnosis of Schizophrenia or Dementia or any condition which affects cognition, Patients with visual and hearing impairment, Patients with communication barriers who could not complete the cognition test and patients with pre operative Montreal Cognitive Assessment score less than 26.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine whether the use of intraoperative Dexmedetomidine is associated with a decreased incidence of post-operative cognitive dysfunction in elderly patientsTimepoint: MOCA scale will be used to assess patients cognition status before surgery <br/ ><br>and <br/ ><br>1 hour after surgery <br/ ><br>6 hours after surgery <br/ ><br>24 hours after surgery and preoperative and postoperative cognition scores will be compared

Secondary Outcome Measures

Name	Time	Method
To determine at which dose Dexmedetomidine has a more favourable effect on postoperative cognitive dysfunction and whether Dexmedetomidine plays a role in post operative analgesia.Timepoint: For 1 hour,6 hours, and 24 hours after end of general anesthesia.