Comparison of two doses of Dexmedetomidine to assess change in blood pressure as a response during vocal cord surgeries
Not Applicable
- Conditions
- Health Condition 1: D141- Benign neoplasm of larynxHealth Condition 2: C320- Malignant neoplasm of glottis
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
American Society of Anaesthesiologists- Grade I and II
Exclusion Criteria
1. Patients with baseline hemodynamic instabilities(Heart Rate <45bpm , Mean arterial pressure <65mm Hg)
2. Tracheostomized patients
3. Allergy to Dexemedetomidine
4. Co-existing cardiac, hepatic and renal dysfunctions
5. History of cerebro-vascular accidents
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the effect of two dosages of Dexmedetomidine infusion (0.5mcg/kg/hr <br/ ><br>vs 0.7mcg/kg/hr) on mean arterial pressures in patients undergoing microlaryngeal <br/ ><br>surgeriesTimepoint: 1. At 0 min(loading dose) <br/ ><br>2. At 5 mins after loading dose <br/ ><br>3. At 10 mins after loading dose <br/ ><br>4. At start of Dexmedetomidine infusion <br/ ><br>5. At the time of induction with Propofol <br/ ><br>6. Every 1min till 5 mins after intubation <br/ ><br>7. At introduction of suspension laryngoscopy <br/ ><br>8. 1 min after microlaryngoscopy <br/ ><br>9. 5mins after microlaryngoscopy <br/ ><br>10. Every 5 mins thereafter till the end of surgery <br/ ><br>11. At extubation <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1. To compare the effect of two dosages of Dexmedetomidine (0.5mcg/kg/hr vs 0.7 mcg/kg/hr) on heart rate in patients undergoing microlaryngeal surgeries. <br/ ><br>2. To compare the incidence of cough as a quality of extubation using a 5-point cough scale. <br/ ><br>3. To compare the recovery times in both groupsTimepoint: 1. At 0 min(loading dose) <br/ ><br>2. At 5 mins after loading dose <br/ ><br>3. At 10 mins after loading dose <br/ ><br>4. At start of Dexmedetomidine infusion <br/ ><br>5. At the time of induction with Propofol <br/ ><br>6. Every 1min till 5 mins after intubation <br/ ><br>7. At introduction of suspension laryngoscopy <br/ ><br>8. 1 min after microlaryngoscopy <br/ ><br>9. 5mins after microlaryngoscopy <br/ ><br>10. Every 5 mins thereafter till the end of surgery <br/ ><br>11. At extubation