NCT02378376已完成不适用
In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon After Consumption of Different Cereal Fractions.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 10
- 主要终点
- Quantification of acetate, propionate and butyrate production in the colon after consumption of each wheat derived fiber fraction
研究概览
简要总结
During this project the amount of SCFA produced in the colon after consumption of 2 different 13C-labelled wheat fiber fractions will be quantified.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Regular diet with 3 meals a day (minimal 5 times a week)
- •BMI between 18.5 and 27 kg/m2
排除标准
- •Calorie restricted diet or other special diet during the study or during the last month prior to the study
- •Antibiotics in the month prior to the study
- •Former surgeries on the gastrointestinal tract, with the exception of an appendectomy
- •use of the following types of medications with effects on the gastrointestinal tract during the last 2 weeks prior to the study (spasmolytica, anti-diarrhea, anti-constipation, probiotics)
- •Chronic disease of the gastrointestinal tract such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, chronic constipation, chronic frequent diarrhea, clinically relevant lactose intolerance
- •Pregnancy, pregnancy desire or breastfeeding
- •Diabetes (type 1 and 2)
- •Blood donation in the past 3 months prior to the study
- •Abnormal hemoglobin (Hb) levels in blood, men must have a Hb level between 14.0 and 18.0 g / dL and women between 12.0 and 16.0 g / dL
- •Participation in studies in the past year in which radiation was used.
结局指标
主要结局
Quantification of acetate, propionate and butyrate production in the colon after consumption of each wheat derived fiber fraction
时间窗: 2 years
次要结局
未报告次要终点
研究者
Kristin Verbeke
Professor Kristin Verbeke
KU Leuven
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