Assessment of small airway diseases by inert gas washout testing. Evaluation of N2-single and multiple breath washout versus a double tracer single breath technique in healthy adults and patients with small airway diseases

• Conditions: Obstructive lung diseases, asthma, COPD, cystic fibrosis; J45; J44.9; E84; Asthma; Chronic obstructive pulmonary disease, unspecified; Cystic fibrosis

• Registration Number: DRKS00003541
• Lead Sponsor: Klinik Schillerhöhe, Robert-Bosch-Krankenhaus-GmbH,Akademisches Lehrkrankenhaus der Universität Tübingen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-04-04
• Study Completion: 2014-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 107

Inclusion Criteria

Healthy adults: Healthy nonsmoking adults 18-70 years without prior lung diaseases.
Asthma patients: Clinical diagnosis of Asthma. Treatment step 2-4 (GINA). No history of smoking. ACT > 20 pts.
COPD patients: Clinical diagnosis of COPD. GOLD I-III. Smoking history > 10 PY.
Cystic fibrosis patients: Clinical diagnosis of CF. No history of smoking. FEV1 > 40 % pred.

Exclusion Criteria

Age < 18 years,
Incapable of giving consent to the study,
Pregnancy,
Severe cardiac comorbidity,
Known intolerance to salbutamol
Respiratory infection or change of medication
within the last 3 months

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Variability and reproducability of Nitrogen-Single Breath Washout Test (N2-SBW), Nitrogen-Multiple Breath Washout Test (N2-MBW) and Double Tracer Gas Singl Breath Washout Test (DTG-SBW parameters).<br>Differences in N2-SBW, N2-MBW and DTG-SBW parameters between patient populations

Secondary Outcome Measures

Name	Time	Method
Define new Double Tracer Gas Single Breath Washout Test parameters