Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery
- Conditions
- LidocaineQuality of Recovery(QoR-40), Preoperative and PostoperativeDexmedetomidine
- Interventions
- Registration Number
- NCT04706767
- Lead Sponsor
- Anqing Municipal Hospital
- Brief Summary
BACKGROUND: Some studies have revealed that intravenous (IV) lidocaine or dexmedetomidine might improve the quality of recovery undergoing laparoscopic surgery. The investigators investigated whether co-administration lidocaine and dexmedetomidine could better improve the the quality of recovery after laparoscopic total hysterectomy.
METHODS: One hundred and forty-four women with elective laparoscopic total hysterectomy were randomly divided into four groups: Patients in group L received a bolus infusion of lidocaine (2%; 1.5 mg/kg over 10 min before the induction of anesthesia), and then lidocaine was infused at a rate of 1.5 mg/kg/h until close the pneumoperitoneum. Patients in group D received a bolus infusion of dexmedetomidine (0.5 µg/kg over 10 min before the induction of anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until close the pneumoperitoneum. Patients in group LD received a bolus infusion of lidocaine (2%; 1.5 mg/kg) and dexmedetomidine (0.5 µg/kg) over 10 min before the induction of anesthesia, and then lidocaine and dexmedetomidine were infused at a rate of 1.5 mg/kg/h and 0.4 µg/kg/h until close the pneumoperitoneum, respectively. Patients in group C received the same volume of normal saline 10 min before the induction of anesthesia, and then normal saline (0.9%) was continuously infused in an equal volume until close the pneumoperitoneum. Primary outcome was the quality of recovery (QoR-40) at 1 day prior to sugery, 1 day after sugery, and 2 days after sugery. The secondary outcomes included perioperative remifentanil consumption, postoperative VAS scores, the incidence of postoperative nausea and vomiting, postoperative rescue analgesics and anti-emetics, recovery time, extubation time, and Ramsay sedation scale at 5 min, 10min, 30 min, 60 min after extubation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 160
- American Society of Anesthesiologists (ASA) physical statusⅠand Ⅱ
- Scheduled for elective laparoscopic total hysterectomy
- History of allergy to local anesthetics
- BMI>30
- Severe respiratory disease
- Renal or hepatic insufficiency
- History of preoperative opioids medication and psychiatric
- preoperative bradycardia
- preoperative atrioventricular block
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Effect of Lidocaine infusion on Quality of Recovery Dexmedetomidine infusion - Effect of Dexmedetomidine infusion on Quality of Recovery Dexmedetomidine infusion - Effect of Lidocaine infusion on Quality of Recovery Lidocaine infusion - Effect of saline infusion on Quality of Recovery Lidocaine infusion - Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery Dexmedetomidine infusion - Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery Lidocaine infusion - Effect of Lidocaine infusion on Quality of Recovery Saline infusion - Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery Co-administration Lidocaine and Dexmedetomidine - Effect of saline infusion on Quality of Recovery Dexmedetomidine infusion - Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery Saline infusion - Effect of Dexmedetomidine infusion on Quality of Recovery Lidocaine infusion - Effect of Lidocaine infusion on Quality of Recovery Co-administration Lidocaine and Dexmedetomidine - Effect of Dexmedetomidine infusion on Quality of Recovery Co-administration Lidocaine and Dexmedetomidine - Effect of saline infusion on Quality of Recovery Co-administration Lidocaine and Dexmedetomidine - Effect of Dexmedetomidine infusion on Quality of Recovery Saline infusion - Effect of saline infusion on Quality of Recovery Saline infusion -
- Primary Outcome Measures
Name Time Method Quality of recovery scores(QoR-40) 1 day after operation Our primary outcome was Quality of recovery scores(QoR-40) 1 day after operation
- Secondary Outcome Measures
Name Time Method Intraoperative remifentanil total dose Intraoperative Secondary Outcome Measure was remifentanil total dose during the perioperative period
Pain visual analogue scale scores The first 24 hours after operation Secondary Outcome Measure was pain visual analogue scale scores
The length of post-anesthesiacare unit stay Immediately after the surgery Secondary Outcome Measure was the length of post-anesthesiacare unit stay
Recovery time Immediately after the surgery Secondary Outcome Measure was recovery time
The consumption of sufentanil The first 24 hours after operation Secondary Outcome Measure was consumption of sufentanil
Extubation time Immediately after the surgery Secondary Outcome Measure was extubation time
PONV scores The first 24 hours after operation Secondary Outcome Measure was PONV scores
Trial Locations
- Locations (1)
Department of Anqing Hospital Anesthesiology
🇨🇳Anqing, Anhui, China