"Effect of Anodal transcranial direct current stimulation on attention and executive function in stroke survivors - An experimental study.
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- 1. Stroop test
研究概览
简要总结
After a stroke, cognitive impairment significantly increases disability. Working memory and executive function deficiencies are particularly prevalent, chronic, and strongly related to restrictions in daily living tasks. The executive control, default mode network, and salience network are among the functional brain networks hypothesized to be affected locally and globally by post-stroke executive dysfunction.
Cognitive areas including spatial awareness, attention, vision, memory, language, and executive function can all be impacted by alterations in the brain. Physical therapy is frequently employed in stroke recovery and has been shown to enhance brain plasticity following localized neurological dysfunction.
The effectiveness of transcranial direct current stimulation (tDCS) in enhancing executive function in these populations depends on underlying internal mechanisms, including raising cerebral blood flow perfusion, raising cerebral blood flow velocity, lowering -aminobutyric acid (GABA) synaptic activity, raising NMDA receptor function, and modifying synaptic plasticity.
As the cognition factor is mostly ignored consequence in stroke survivors, convectional therapy may improve the cognition status. Transcranial direct current stimulation is novice approach and it has been proved effective in enhancing motor functions in stroke population. Therefore in this research we are focusing on the effect of TDCS on impaired cognition particularly on attention and executive function in stroke survivors.
Transcranial direct current stimulation (tDCS) is effective in improving cognition but its effect is unclear for specific domain. Therefore, there is a need to study the effect of tDCS on specific domains of cognition such as attention and executive function. The stroke population is primarily impacted in these cognitive areas.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)(—)
- 性别
- All
入选标准
- •Acute stroke patients.
- •Both genders.
- •MoCA score between 15-25 (mild to moderate cognition).
排除标准
- •Subjects having metal implants within the skull.
- •Hemodynamically unstable patients.
- •Uncooperative patients or patients not willing to participate.
- •Preceding epilepsy.
结局指标
主要结局
1. Stroop test
时间窗: 1. baseline at 1st week | 2. at the end of 4th week.
2. Trail Making Test (TMT)
时间窗: 1. baseline at 1st week | 2. at the end of 4th week.
次要结局
- 1. Montreal Cognitive Assessment (MoCA)(1. baseline at 1st week)
研究者
Dhanashree S Upganlawar
Dr. D.Y. Patil College of Physiotherapy
