Is the effectiveness of Pulmozyme related to timing? Pre or Post Physiotherapy?

Phase 4

Completed

• Conditions: Cystic fibrosis; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12611001041943
• Lead Sponsor: Jenny Bishop

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-10-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1 diagnosis of cystic fibrosis.
2 Clinically stable for one month before randomization.
3 FVC greater than 40% predicted.
4 Reproducible lung function tests.
5 Informed consent.

Exclusion Criteria

1 Inability to comply with protocol
2 Lack of informed consent.
3 Clinical instability
4 Pregnancy or breast feeding.
5 Allergy or intolerance to Pulmozyme..

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in lung function (FEV1/FVC) both acutely and over a 14 day trial period.[14 day]

Secondary Outcome Measures

Name	Time	Method
Sputum weight during the physiotherapy clearance technique, plus one hour afterwards and during a 24 hour period. Exercise tests, maximum VO2 uptake.[During technique, plus one hour and during a 24 hour period]