Effect of gastric acid inhibitor on drug metabolism
- Conditions
- one
- Registration Number
- JPRN-jRCTs041220044
- Lead Sponsor
- Mihoko Yamade
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 20
Healthy subjects who are at least 18 years old at the time of consent.
Who are able to abstain from alcohol and smoking while taking the study medication and for 14 to 28 days during the washout period
Who have signed a consent form to participate in this study.
1. Those with a history of gastric ulcer
2. Those with a history of myocardial infarction
3. Those with serious liver disease (>3 times the reference value)
4. Patients with serious renal disease (Cre > 1.5)
5. Patients who have undergone abdominal surgery
6. Those who have other serious diseases
7. Who are receiving continuous medical treatment during the study period 8. who are receiving continuous medical treatment during the study period
8. Who are allergic to any of the study drugs (esomeprazole or bonoprazan)
9. Pregnant women and those who wish to deliver a baby during the study period;
10.Persons who are deemed inappropriate by the investigator (subinvestigator).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Carbon isotope ratio (13CO2/12CO2) of carbon dioxide in 13C-aminopyrine breath samples after VPZ and EPZ oral administration
- Secondary Outcome Measures
Name Time Method Frequency of adverse events