The impact of continuous versus intermittent feeding on changes in insulin sensitivity during bed-rest

Completed

Conditions: disuse atrophy
10018424

Registration Number: NL-OMON42317

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 35

Inclusion Criteria

* Male
* Aged from 18-35 years
* 18.5 < BMI < 30 kg·m2
* Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 60 minutes)

Exclusion Criteria

* Smoking
* Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
* Hypertension (according to WHO criteria) [16] and/or cardiovascular disease
* Any back/leg/knee/neck/postural complaints
* Type 2 diabetes mellitus
* Any family history of thrombosis
* All co-morbidities interacting with mobility and muscle metabolism of the lower limbs
* (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
* Myocardial infarction within the last 3 years
* Use of certain anti-coagulants (use of thrombocyte aggregation inhibitors such as Ascal, acetylsalicylic acid, aspirin and carbasalaatcalcium is permitted. Use of other thrombocyte aggregation inhibitors will be discussed with the responsible physician)
* A history of deep vein thrombosis (DVT) in the leg
* Having donated blood in the 3 months prior to the study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Peripheral insulin sensitivity (measured as glucose infusion rate, GIR)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Quadriceps cross-sectional area (CSA), whole body lean mass, leg lean mass,<br /><br>mitochondrial function, accumulated (7-day) free-living and bed-rested<br /><br>myofibrillar and mitochondrial fractional synthesis rates, nitrogen balance.</p><br>