Bioavailability and metabolic effects in humans of n-3 polyunsaturated fatty acids and conjugated linoleic acid after consumption of naturally enriched cow milk
Completed
- Conditions
- utritionNutritional, Metabolic, EndocrineNutrition
- Registration Number
- ISRCTN16004121
- Lead Sponsor
- Feiraco Lacteos S.L. (Spain)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 38
Inclusion Criteria
1. Healthy men and women volunteers
2. Aged between 18 and 50 years
3. Overweight (body mass index [BMI] between 25.0 and 29.9 kg/m^2)
4. Sign an informed consent
Exclusion Criteria
1. Subjects with a prior history of cardiovascular disease, cancer, any severe chronic disease, psychiatric condition, alcoholism or drug abuse
2. Milk intolerance
3. Intake of fish oil capsules or fish oil enriched foods in the prior 3 months
4. Consumption of fatty fish more than once per week
5. BMI outside of pre-specified range
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Determination of plasma fatty acid content at baseline and after 6 weeks of consumption of experimental and control milks
- Secondary Outcome Measures
Name Time Method 1. Medical record, including anthropometric measurements (height, weight and waist circumference) and blood pressure at baseline and end of treatment<br>2. Food, energy and nutrient intake assessed by 7-day food records prior to entry and on the last week of intervention<br>3. Blood chemistry, with safety profile (complete blood count, fasting blood glucose, creatinine, uric acid, alanine aminotransferase [ALT], aspartate aminotransferase [AST], gamma-glutamyl transferase [GGT], and total protein) and lipid profiles (total cholesterol, high density lipoprotein [HDL] cholesterol, low density lipopotein [LDL] cholesterol and triglycerides) at baseline and the end of treatment