The Effect of Transcranial Direct Current Stimulation on Intelligence Quotient in Children With Autism Spectrum Disorders

Phase 2

• Conditions: anodal tDCS through the left dorsolateral prefrontal cortex (DLPFC) can enhance neural connectivity in the fronto-parietal networks and can increase intelligence in individuals with autism. Therefore, this study aimed to investigate the effect of anodal tDCS on IQ changes in high function autism spectrum disorder patients.; Autism spectrum disorder; Intelligence quotient; Transcranial direct current stimulation

• Registration Number: TCTR20221018005
• Lead Sponsor: Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-18
• Study Completion: 2022-10-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

The inclusion criteria were as follows: (a) mild to moderate autistic symptoms (Childhood Autism Rating Scale, CARS score 30-36.5) where the patient can co-operate in IQ examination; (b) aged between 15 and 30 years; (c) normal brain structure evaluated by MRI; and (d) the caregiver together with the patients consented to participate in the research.

Exclusion Criteria

The exclusion criteria were as follows: (a) severe neurological disorders such as brain tumor, intracranial infection, and uncontrollable epilepsy; (b) uncooperative parents; and (c) received other new treatments during the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IQ level 2 time points, at baseline and 2 weeks post treatment Test of Nonverbal Intelligence, fourth edition (TONI-IV)

Secondary Outcome Measures

Name	Time	Method
ATEC score 2 time points, at baseline and 2 weeks post treatment Autism Treatment Evaluation Checklist