The effect of Brain Stimulation through the skull bones in the balance after external perturbation in patients with Parkinson's disease

Not Applicable

• Conditions: Posture, Motor disorders, Parkinson's disease, Postural Balance; G00-G99

• Registration Number: RBR-3kc2gd
• Lead Sponsor: niversidade Estadual Paulista (Unesp), Instituto de Biociências (IB)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-01-21
• Last Update Posted: 29 May 2023
• Study Completion: 2023-10-20

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients should be diagnosed with idiopathic Parkinson's Disease based on the UK Brain Bank criteria; aged between 50 and 85 years; both sexes; make regular use of the Parkinson's disease medication

Exclusion Criteria

Patients with score above three in the Hoehn & Yahr scale (H&Y); dementia; change in the Parkinson's Disease medication; musculoskeletal and/or visual impairments that make it impossible to comply the experimental protocol; presence of any uncontrolled disease that could affect peripheral sensory function (e.g., diabetes); risk of receive the stimulation (neural implants, pacemaker, history of seizures and epilepsy)

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It is expected the decrease of the onset latency of medial head of the gastrocnemius muscle (MG) (in ms) and the range of CoP (in cm) in patients with PD, calculated by a semiautomatic custom algorithm developed in Matlab environment, after a session with tDCS (mainly with the intensity with 2 mA).;It is expected the decrease of the onset latency of medial head of the gastrocnemius muscle (MG) (in ms) and the range of CoP (in cm) in patients with PD, calculated by a semiautomatic custom algorithm developed in Matlab environment, immediately after the intervention with multiple sessions of tDCS ends and remain for one month after that.

Secondary Outcome Measures

Name	Time	Method
It is expected the decrease in prefrontal cortex activity in the reactive and increases activity in predictive adjustments with passing the trials, verified through a technique that analyzes the hemodynamic response of the brain (in µmol/l)- functional near-infrared spectroscopy (fNIRS) - after a session with tDCS (mainly with the intensity with 2 mA).<br>;It is expected the decrease in recovery time (in seconds) to the stable position after perturbation, the decrease in prefrontal cortex activity in the reactive and the increase in activity (in µmol/l) in predictive adjustments immediately after the intervention with multiple sessions of tDCS ends and remains for one month after that. The cortical activity is verified through a technique that analyzes the hemodynamic response of the brain - functional near-infrared spectroscopy (fNIRS).