Predictability of central venous to arterial CO2 difference (AVCO2) and inflammatory markers in children with cardiac surgery to poor outcomes

Completed

• Conditions: children age 1 days - 18 year old who undergone open cardiac surgery; carbon dioxide; thoracic surgery; congenital heart disease; post operative period

• Registration Number: TCTR20240615004
• Lead Sponsor: Research Fund, faculty of Medicine

Brief Summary

On comparing laboratory values between the LCOS and non-LCOS groups at all four time points, the VACO2 did not differ; however, the lactate levels in the LCOS group were significantly higher. The VACO2 had a fair-to-weak correlation with the O2ER but did not correlate with the lactate levels. A VACO2 of more than 6 mmHg at 6 h postoperatively was significantly associated with fewer 28-day inotrope-free days and ICU-free days.

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-12-15
• Study Start: 2024-06-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 127

Inclusion Criteria

1. Children aged 0-18 years old with either congenital or acquired cardiac disease
2. Undergone cardiopulmonary bypass for cardiac surgery
3. Be admitted in PICU for post-operative care

Exclusion Criteria

1. Preterm infant (GA < 37 weeks) or weight less than 2 kg
2. Patient who weaned off cardiopulmoanry bypass and required extracorporeal membrane oxygenator (ECMO) before leaving the operating room
3. Patient who required emergency cardiac operation within 24 hour after hospitalization
4. Patient who had significant residual left side outflow tract obstruction (e.g., coarctation of aorta, interrupted aortic arch) which defined by difference of SBP between upper and lower extremities more than 10 mmHg
5. Patient who had already participated in another research project
6. Patient who does not have both arterial line and central line catheter back from operating room
7. Parents or legal guardian refuse to inform consent.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
low cardiac output related outcomes 24 hour post operation composite outcomes which include both clinical and laboratory value

Secondary Outcome Measures

Name	Time	Method
28-free day mechanical ventilator 28 days post operation the number of days patients were alive and free from ventilatorwithin 28 days by counting the day of first operative night as the first day,28-free ICU day 28 day post operation the number of days patients were alive and free from ICU stay within 28 days by counting the day of first operative night as the first day,28-free inotrope day 28 day post operation the number of days patients were alive and free from inotrope within 28 days by counting the day of first operative night as the first day