Effect of characters of male blood donors on maintenance of pre-transfusion hemoglobin levels in thalassemic childre
- Conditions
- Health Condition 1: D644- Congenital dyserythropoietic anemia
- Registration Number
- CTRI/2023/03/050299
- Lead Sponsor
- Department of Transfusion Medicine GMCH-32
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Male blood donors in the age group of 18-30 years and 45-65 years and meeting all other criteria for whole blood donation as per guidelines laid by Drug Controller General of India (DCGI).
Thalassemia children receiving blood transfusions at Government Medical College and Hospital, Chandigarh only.
Thalassemia children in the age group of 3-9 years.
Blood donors not meeting eligibility criteria laid down by the DCGI.
Male donors between 31- 44 years of age.
Female blood donors.
Thalassemic children having - Clinical evidence of hypersplenism
- Presence of auto antibody
- Presence of unidentifiable alloantibodies
- Fever / acute infection
- Congestive Cardiac Failure (CCF)
- If volume of transfusion required is <100 or >600ml.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method â??Maintaining pre-transfusion haemoglobin of 9-10.5 g/dl. <br/ ><br>â??Number of donor exposures to the patient.Timepoint: â??Maintaining pre-transfusion haemoglobin of 9-10.5 g/dl after 3 weeks of transfusion. <br/ ><br>â?? Number of donor exposures to the patient after 3 months
- Secondary Outcome Measures
Name Time Method Comparing the iron overload in two groups by measuring the change in serum ferritin levels during the study period. <br/ ><br>Timepoint: 3 months