The effect of lutein-enriched-egg beverage on progression of Age-related Macular Degeneration, a randomized trial
Completed
- Conditions
- age related macular degenerationmacula10047060
- Registration Number
- NL-OMON33516
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 220
Inclusion Criteria
- Early signs of AMD on fundus photo (drusen, REP changes)
- 50 years and older
- visus > 0.5
- non-smoker (for at least 2 years)
- clear optical media
- no use of supplementation containing lutein or zeaxanthin
- BMI < 30
- No heart disease
Exclusion Criteria
- Diabetes
- Lipid metabolism disease
- Use of statins
- Egg allergie
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Measuring macular pigment optical density, the amount of measurable macular<br /><br>pigment in the macula region. Changes in amount of early macular degeneration<br /><br>signs on fundus photographs (drusen or retinal pigment epithelium changes).<br /><br>Contrast sensitivity.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Assessing morphological changes of the retina, visual acuity, plasma lutein and<br /><br>zeaxanthin levels, field of vision, and rod function. Vascular function by<br /><br>means of Intima media thickness, flow mediated vasodilatation, arterial<br /><br>distensibility, and lipid metabolism will also be measured in the course of<br /><br>this trial.</p><br>