Speed of Glucose Absorption During Exercise

Not Applicable

Completed

• Conditions: Healthy Nutrition; Healthy

• Registration Number: NCT06768333
• Lead Sponsor: Lancaster University

Brief Summary

The purpose of this study is to look at how fast commercially available supplements containing carbohydrates can get into the bloodstream during repeated sprint cycles. This will build from a pervious study where the investigators tested these supplements on healthy participants during a resting oral glucose tolerance trial. The investigators will be testing three supplements, namely Voom Pocket Rocket, SIS Go Isotonic Energy Gel, and Maurten Gel 160. Each participant will complete all three conditions, consuming one of each supplement at random per condition. The study requires participation from male and female runners, cyclists and triathletes who are aged between 18-40.

Each visit will take approximately 1 hour, and three experimental visits per participant. The study will involve frequent blood sampling and the continuous monitoring of gas exchange (oxygen/carbon dioxide). Blood sampling via cannulation will be used to analyse the lactate, glucose, and electrolyte content of the blood. Gas exchange will measure the oxygen breathed in and carbon dioxide breathed out throughout the exercise.

The investigators plan to carry out the study on 10 participants who will be a mix of male and female runners, cyclists and triathletes.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-01
• Study Start: 2025-01-06
• Study First Submitted: 2025-01-06
• Study First Submitted QC: 2025-01-06
• Study First Posted: 2025-01-10
• Primary Completion: 2025-02-05
• Study Completion: 2025-02-05
• Last Update Submitted: 2025-03-03
• Last Update Posted: 2025-03-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Aged between 18-40 years
• Male or female
• Tier 2 athletes - local level representation, training ~ 3 times per week, training with a purpose to compete, identify with a specific sport, limited skill development (McKay et al., 2021)

Exclusion Criteria

• Allergies to any listed ingredients on any supplements.
• Diabetes (type 1 or 2)
• Any medical conditions
• Smokers
• Any injury that would prevent them from exercising
• Anyone using drugs or medication (not including contraception)
• Anyone consuming alcohol within 24 hours of the study
• Exercise must be restricted within 24 hours of the study
• Caffeine must not be consumed within 24 hours of testing as it can significantly enhance carbohydrate oxidation rates (Yeo et al., 2005)
• Diets including high-carbohydrate-low-fat (HCLF), low-carbohydrate-high-fat (LCHF), ketogenic, and/or glycogen manipulation diets (Rauch et al., 2022)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Blood Glucose	Blood glucose measures will be taken 35 minutes after consuming the supplement(s) (baseline), after the 3 minute warmup, and then after every 15 second sprint and every 3 minute period of active recovery	Frequent blood sampling for blood glucose (1ml after every stage of both sprint cycling and active recovery) followed by analysis in the Biosen Analyser
Blood Lactate	Blood lactate measures will be taken 35 minutes after consuming the supplement(s) (baseline), after the 3 minute warmup, and then after every 15 second sprint and every 3 minute period of active recovery	Frequent blood sampling for blood lactate (1ml after every stage of both sprint cycling and active recovery) followed by analysis in the Biosen Analyser
Gas Exchange	Gas exchange will be measured continuously throughout the 20 minutes of exercise, starting at the warmup	Gas exchange measured throughout each 20 minute exercise via a Cortex Metalyzer

Secondary Outcome Measures

Name	Time	Method
Gastrointestinal (GI) Discomfort Questionnaire	GI Discomfort will be measured 5 minutes before and 5 minutes after exercise	Participants will complete a GI discomfort questionnaire 5 minutes before starting exercise and at the end of exercise
Blood electrolyte content	Blood electrolyte measures will be taken 35 minutes after consuming the supplement(s) (baseline), after the 3 minute warmup, and then after every 15 second sprint and every 3 minute period of active recovery	Frequent blood sampling for electrolyte concentrations of the blood (sodium, potassium, chloride, calcium) (1ml after every stage of both sprint cycling and active recovery) followed by analysis in the Biosen Analyser
Rate of Percieved exertion (RPE)	RPE will be measured at the end of the warmup and the end of the final sprint stage	Participants will report their RPE using the Borg Scale to report how hard they are finding the exercise. This will be done after the warm-up and after the final sprint.

Trial Locations

Locations (1)

Lancaster University; 🇬🇧 Lancaster, Lancashire, United Kingdom