A comparative study to evaluate the effectiveness of aqueous extracts of Navakarshika kwatham and Trinapanchamoola kwatham in Hyperuricemia.

Uric acid is the final byproduct of purine metabolism , which is produced by xanthine oxidase".

Elevated levels of serum uric acid are a hall mark of hyperuricemia’. Hyperuricemia is defined as a plasma(or serum) urate concentration > 405 M mol/L (6.8 mg/dL)’. According to estimates, hyperuricemia affects up to 21% of the general population and 25% of hospitalized patients’ .

Hyperuricemia related conditions mainly include gout. Hyperuricemia causes endothelial dysfunction by causing an increase in inflammation and oxidative stress which is associated with dyslipidemia,diabetes mellitus,hypertension and menopause.

Hyperuricemia results due to uric acid metabolism impairment and can be correlated to pitta pradhana dosha dushti ,which is rasa-raktha dhatu asritha and is brought on by rasa-raktha dhatwagni mandyam. Present study will be conducted to compare the effectiveness of Navakarshika kwatham given as aqueous extract mentioned in Chakradutta Vataraktha chikitsa’ and Trinapanchamoola kwatham given as aqueous extract mentioned in Sahasrayogam Mutrakrichra chikitsa’ in hyperuricemia.A comparative study will be conducted in consecutive cases attending OPD of Kayachikitsa,Govt Ayurveda college;Thiruvananthapuram having hyperuricemia and are divided into 2 groups;each having 22 participants of age group 30-60 years. Group A will be intervened by Navakarshika kwatham  and Group B with Trinapanchamoola kwatham . Drugs administered for 30 days and serum uric acid level will be estimated for clinical evaluation both before and after the intervention.