A Comparative Analysis of Preoperative Liver Volumetry in Living Donor Liver Transplantation

Completed

• Conditions: Living Donor Liver Transplantation; Liver Failure

• Registration Number: NCT06865612
• Lead Sponsor: Chungnam National University Hospital

Brief Summary

Accurate preoperative graft volume assessment is crucial for successful living donor liver transplantation (LDLT). Although manual and automated computed tomography (CT) volume measurement methods using various volumetric tools are widely used, their accuracy remains uncertain. This study aimed to determine the optimal dry weight correction factor for each method to enhance the prediction of actual graft weight (AGW) and compare the accuracy of different methods.

Detailed Description

This study is a retrospective diagnostic accuracy study comparing three liver volumetry methods using preoperative donor CT scans in LDLT.

Study Timeline

• Study Start: 2011-11-01
• Primary Completion: 2024-12-31
• Study Completion: 2025-01-31
• Status Verified: 2025-02
• Study First Submitted: 2025-03-06
• Study First Submitted QC: 2025-03-06
• Last Update Submitted: 2025-03-06
• Study First Posted: 2025-03-10
• Last Update Posted: 2025-03-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 109

Inclusion Criteria

• Patients who underwent hepatectomy for living donor liver transplantation performed by the Department of Surgery at Chungnam National University Hospital under the supervision of the principal investigator.

Exclusion Criteria

• Patients deemed unsuitable for participation in this clinical study by the investigator.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Accuracy of preoperative estimated graft volume (EGV) compared to actual graft weight (AGW)	From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)	The accuracy of preoperative donor CT liver volumetry will be assessed by comparing estimated graft volume (EGV) obtained from three methods (automated, semi-automated, manual) with the actual graft weight (AGW) measured intraoperatively. The error ratio between EGV and AGW will be calculated for each method.

Secondary Outcome Measures

Name	Time	Method
Determination of the optimal dry weight correction factor for each volumetry method	From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)	The study aims to determine the optimal dry weight correction factor by minimizing the discrepancy between EGV and AGW.

Trial Locations

Locations (1)

Chungnam National University Hospital; 🇰🇷 Daejeon, Korea, Republic of