The effect of Telmisartan on inflammatory processes in the vascular wall of abdominal aortic aneurysms.
Phase 2
- Conditions
- abdominal aortic aneurysm. aneurysm.10002363
- Registration Number
- NL-OMON43688
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
Patients with an abdominal aortic aneurysm who are planned for elective open surgical repair.
Exclusion Criteria
1. Renal insufficiency; eGFR < 50 ml/min
2. Bloodpressure < 120/70 mmHg
3. Abnormal liver function (liver enzymes > 3 times elevated of normal value)
4. Hypersensitivity for angiotensin II type 1 receptor antagonist or ACE inhibitor
5. Current usage of angiotensin II type 1 receptor antagonist or ACE inhibitor
6. Known significant renal stenosis (>70%) of one or both renal arteries
7. Active gout
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Exploratory pathway analysis of markers for inflammation, cell proliferation<br /><br>and matrix remodeling.</p><br>
- Secondary Outcome Measures
Name Time Method <p>n.a.</p><br>