The effect of the anti-hypertensive drug Telmisartan on inflammation in the vascular wall of an aneurysm of the abdominal aorta.
- Conditions
- Abdominal aortic aneurysm with an indication for elective open surgical repair.Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]
- Registration Number
- EUCTR2015-003674-32-NL
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Patients with an abdominal aortic aneurysm who are planned for elective open surgical repair.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) no
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 15
Exclusion Criteria
1. Renal insufficiency; eGFR < 50 ml/min
2. Bloodpressure < 110/70 mmHg
3. Abnormal liver function (liver enzymes > 3 times elevated of normal value)
4. Hypersensitivity for angiotensin II type 1 receptor antagonist or ACE inhibitor
5. Current usage of angiotensin II type 1 receptor antagonist or ACE inhibitor
6. Known significant renal stenosis (>70%) of one or both renal arteries
7. Active gout
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method