Validation of four quantitative radiological techniques to image cartilage quality in patients with knee osteoarthritis scheduled to undergo total knee replacement. - QUICK study

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 25 人开始时间: 待定最近更新: 2024年4月29日

适应症

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•Patient is older than 18 years, knee pain for more than one month, a discrepancy in radiological OA stage between both compartments of the tibiofemoral joint (one compartment severe and one compartment mild to moderate OA according to Kellgren & Lawrence, and one of the following: patient is older than 38 years, there is less than 30 minutes of morning stiffness in the knee or crepitures and bony enlargement are present during physical examination.

•Severe knee OA without asymmetric distribution in severity between both compartments of the tibiofemoral joint, varus or valgus deformity in the knee > 10 degrees, chondrocalcinosis, absolute and relative contra-indications to undergo MRI: brain aneurysm clip, implanted neural stimulator, cardiac pacemaker or defibrillator, cochlear implant, ocular foreign body, other implanted medical devices: (e.g. catheters, insulin pump, metal shrapnel or bullet or metallic implant in the region of the target knee joint), pregnancy, lactating women, renal insufficiency (defined by a glomerular filtration rate of <60 milliliter/minute), allergy to contrast agents for dGEMRIC or CTa (Magnevist ®, Bayer Schering AG, Berlin, Germany or Hexabrix 320, Mallinckrodt, Hazelwood, MO, USA), alcoholism or insufficient command of the Dutch language: spoken and/or written.

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