NL-OMON37160
Completed
Not Applicable
Validation of four quantitative radiological techniques to image cartilage quality in patients with knee osteoarthritis scheduled to undergo total knee replacement. - QUICK study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- knee osteoarthritis
- Sponsor
- Erasmus MC, Universitair Medisch Centrum Rotterdam
- Enrollment
- 25
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient is older than 18 years, knee pain for more than one month, a discrepancy in radiological OA stage between both compartments of the tibiofemoral joint (one compartment severe and one compartment mild to moderate OA according to Kellgren \& Lawrence, and one of the following: patient is older than 38 years, there is less than 30 minutes of morning stiffness in the knee or crepitures and bony enlargement are present during physical examination.
Exclusion Criteria
- •Severe knee OA without asymmetric distribution in severity between both compartments of the tibiofemoral joint, varus or valgus deformity in the knee \> 10 degrees, chondrocalcinosis, absolute and relative contra\-indications to undergo MRI: brain aneurysm clip, implanted neural stimulator, cardiac pacemaker or defibrillator, cochlear implant, ocular foreign body, other implanted medical devices: (e.g. catheters, insulin pump, metal shrapnel or bullet or metallic implant in the region of the target knee joint), pregnancy, lactating women, renal insufficiency (defined by a glomerular filtration rate of \<60 milliliter/minute), allergy to contrast agents for dGEMRIC or CTa (Magnevist ®, Bayer Schering AG, Berlin, Germany or Hexabrix 320, Mallinckrodt, Hazelwood, MO, USA), alcoholism or insufficient command of the Dutch language: spoken and/or written.
Outcomes
Primary Outcomes
Not specified
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