Comparison of two methods of tapering Naloxone in methadone poisoned patients

Phase 3

Recruiting

• Conditions: on-addicted patients with methadone poisoning.; Poisoning by, adverse effect of and underdosing of methadone; T40.3X

• Registration Number: IRCT20220305054196N1
• Lead Sponsor: Toxicological Research Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 30 May 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patients with methadone toxicity
Age over 18 years

Exclusion Criteria

Opioid addiction
Concomitant poisoning with methadone and other drugs, especially sedatives
Patients who do not need Naloxone treatment
Patients with heart failure
patients with renal failure
patients being treated with Methadone Maintenance Treatment method

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction of consciousness level during tapering of Naloxone. Timepoint: Initiate treatment and then assess the patient's consciousness every 3 hours. Method of measurement: Using the Glasgow Coma Scale (GCS).;Respiratory depression of the patient during reducing the dose of naloxone every 3 hours. Timepoint: Assess the patient's condition every 1 hours. Method of measurement: Based on respiration rate per minute.