Comparison of naloxone and naltrexone in the treatment of methadone poisoning in patients referred to the emergency department
Phase 3
- Conditions
- Poisoning by methadone.
- Registration Number
- IRCT2016100623552N11
- Lead Sponsor
- Vice Chancellor for research of Arak University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
age 20 to 60 years, obtaining informed consent from a parent or guardian patients into the study.
Exclusion criteria: drug, pregnancy and breastfeeding, history of uncontrolled systemic underlying disease, especially liver disease (liver failure, hepatitis, etc.), cardiovascular disease and heart rhythm, especially supraventricular dysrhythmias ; at the same time multiple trauma, especially trauma to the head and the possibility of increased ICP; a history of seizures; a history of hypersensitivity to naloxone or naltrexone consumption in the past; recent use of narcotic analgesics, complications during the administration of a drug abuser
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method evel of consciousness. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Increasing the level of consciousness.;Respiratory function. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Improve respiratory function.
- Secondary Outcome Measures
Name Time Method The number of heart beats per minute. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Measurable clinical responses.;Respiratory rate. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Measurable clinical responses.;Body temperature (° C). Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Measurable clinical responses.;Systolic and diastolic blood pressure. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Measurable clinical responses.