Impact of Chorioamnionitis on Maternal and Fetal Levels of Proinflammatory S100A12
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 69
- 主要终点
- S100A12 in Presence of Maternal Chorioamnionitis
研究概览
简要总结
Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS) and increased levels of proinflammatory molecules.
详细描述
Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS). The aim of this pilot study was to evaluate S100A12, a marker of innate immune activation, in mothers with or without HCA and in their infants.
Concentrations of S100A12, Interleukin 6 (IL-6) and C-reactive protein (CRP) were evaluated in maternal, cord, and neonatal blood of very preterm infants. Histologic examinations of placentae and umbilical cords were performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Preterm Birth
排除标准
- •Congenital Abnormalities
结局指标
主要结局
S100A12 in Presence of Maternal Chorioamnionitis
时间窗: 1 Year
Levels of S100A12 in Maternal, Cord and Neonatal Blood in the Presence or Absence of HCA
次要结局
未报告次要终点
研究者
MARIA PIA DE CAROLIS
MD
Catholic University of the Sacred Heart