Endothelin Concentrations in a Population With Cardiovascular Disease and Periodonitis

Completed

• Conditions: Serum; Disease
• Interventions: Other: Observation

• Registration Number: NCT04152005
• Lead Sponsor: University of Messina

Brief Summary

Recently, a key role played in the ethiology of periodontitis has been highlighted by a Endothelin (ET-1). ET1 possess the ability to express surface antigens of endothelial and hematopoietic stem cells and to assist in maintaining vascular integrity and the repair mechanism of the endothelium. ET originate from bone marrow

Detailed Description

The aim of the present study was to investigate the association between ET-1 in patients with periodontitis. Furthermore, the objective was to determine if the periodontal status influenced ET-1 levels.

Study Timeline

• Study Start: 2016-01-01
• Primary Completion: 2018-09-25
• Study Completion: 2018-09-30
• Status Verified: 2019-11
• Study First Submitted: 2019-11-01
• Study First Submitted QC: 2019-11-01
• Last Update Submitted: 2019-11-04
• Study First Posted: 2019-11-05
• Last Update Posted: 2019-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 165

Inclusion Criteria

• Presence of at least 16 teeth

• CP with a minimum of 40% of sites with a clinical attachment level (CAL)

  ≥2mm and probing depth (PD) ≥4mm;

• Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs

• Presence of ≥40% sites with bleeding on probing (BOP)

Exclusion Criteria

• Intake of contraceptives
• Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
• Status of pregnancy or lactation
• Previous history of excessive drinking
• Allergy to local anaesthetic
• Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control	Observation	Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease
Periodontitis+Cardiovascular	Observation	Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease
Periodontitis	Observation	Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease
Cardiovascular	Observation	Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease

Primary Outcome Measures

Name	Time	Method
Evaluation of ET-1 levels	1 year	Correlation of ET-1 levels with periodontal and cardiovascular disease

Trial Locations

Locations (1)

University of Messina; 🇮🇹 Messina, Italy