Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation

• Conditions: Food Preferences; Taste Disorders; Chronic Renal Failure; Cirrhosis; Protein-Energy Malnutrition

• Registration Number: NCT02931812
• Lead Sponsor: University of Burgundy

Brief Summary

This study evaluates the influence of the taste sensitivity, of food preferences and of the reward system on the energetic balance before and after liver transplantation in cirrhotic patients and after kidney transplantation in renal failure patients

Detailed Description

Background and Aims: Protein-energy malnutrition is associated to cirrhosis with a high prevalence and greatly increases the morbidity and mortality of the disease. Malnutrition results of numerous causes including intestinal malabsorption, increased energy resting expenditure, metabolism disturbances, impaired sensory taste and changes in food preferences which might participate to a reduction in food intake. The aim of this study was to determine the relationships that may exist between taste sensitivity and food preferences on the one hand, eating habits, nutritional status, energy balance and biological parameters including amino acids on the other hand in patients with end-stage cirrhosis and in patients with renal failure.

Fifteen end-stage cirrhotic patients and 15 renal failure patients will be included and matched with 30 healthy subjects. The following parameters will be evaluated during a morning testing session: gustatory sensitivity using a triangular detection threshold method for sweet, salty and umami solutions; preferences for fat- and carbohydrate-rich foods using the PrefQuest score; liking for six foods (protein-, carbohydrate- and fat-rich foods) and wanting for 18 foods (photographs); hunger sensation; energy intake (24 h ingested food); body composition (BMI and impedancemetry); resting energy expenditure (indirect calorimetry) and physical activity (questionnaire). Several plasmatic parameters (amino-acids, leptin, ghrelin, lipid profile) will be also determined.

Study Timeline

• Study Start: 2014-05
• Study First Submitted: 2016-10-03
• Study First Submitted QC: 2016-10-10
• Study First Posted: 2016-10-13
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-07
• Last Update Posted: 2019-10-08
• Primary Completion: 2020-05
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• written consent
• patients in waiting renal transplant
• patients in waiting liver transplant

Exclusion Criteria

• chronic infection
• acute infection
• cancer
• antibiotic treatments
• alcool abuse
• pregnant woman
• specific or restrictive diet

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
body composition	2 years	Device: Multifrequency bio-impedancemetry (aminostats)
amino acids profil in plasma	2 years	Biological measurments
Energy expenditure	two years	evice: indirect calorimetry (sensormedics)
Food preferences	2 years	Device: Treshold taste detection

Trial Locations

Locations (1)

Center for Taste and Feeding Behaviour; 🇫🇷 Dijon, Burgundy, France