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临床试验/CTRI/2025/11/097157
CTRI/2025/11/097157尚未招募不适用

Developing Predictive Models for Classifying Infection vs. Malignancy in PET/CT Imaging of Lung, Head and Neck, and Breast Cancer

Manipal Institute of Technology1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2025年12月1日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
200
试验地点
1
主要终点
Improved diagnostic precision in differentiating infection from malignancy

研究概览

简要总结

This study aims to develop a hybrid predictive model to differentiate infection from malignancy using clinical data, radiomic features, and PET CT metabolic parameters. A comprehensive dataset will be collected, preprocessed, and analyzed. Machine learning methods will be used to identify key features and build a diagnostic model. The performance of the model will be validated and its ability to improve diagnostic accuracy and clinical decision making will be assessed across lung, breast, and head and neck cancer cases.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 90.00 Year(s)(—)
性别
All

入选标准

  • Histopathologically confirmed cases (via biopsy or FNAC) of carcinoma of the lung, breast, or head and neck.
  • Patients undergoing 18F-FDG PET/CT imaging for: Staging or restaging of malignancy; Evaluation of Pyrexia of Unknown Origin (PUO) and/or suspected infectious pathology; Assessment of imaging heterogeneity in known malignancies;
  • Availability of complete PET/CT imaging data in DICOM format
  • Availability of relevant clinical records.

排除标准

  • Incomplete or poor-quality PET/CT imaging
  • Missing or inadequate clinical data
  • Pregnant women and lactating women.

结局指标

主要结局

Improved diagnostic precision in differentiating infection from malignancy

时间窗: 3 years

次要结局

未报告次要终点

研究者

发起方
Manipal Institute of Technology
申办方类型
Research institution
责任方
Principal Investigator
主要研究者

Sandra Sony

Manipal Institute of Technology

研究点 (1)

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