A prospective randomised trial comparing autograft versus homograft aortic root replacement

Royal Brompton and Harefield NHS Foundation Trust (UK)0 个研究点目标入组 228 人开始时间: 2010年3月25日最近更新: 2023年11月20日

适应症

试验速览

2010 Results article in http://www.ncbi.nlm.nih.gov/pubmed/20684981 2023 Other publications in https://pubmed.ncbi.nlm.nih.gov/37938855/ Post hoc analysis (added 09/11/2023)

•1. Patients with symptomatic aortic valve disease requiring aortic valve replacement
•2. Patients with concomitant aortic root dilatation and/or ascending aortic dilatation and aortic valve dysfunction requiring surgery
•3. Patients with bicuspid aortic valve disease requiring aortic valve replacement
•4. Patients with aortic valve endocarditis
•5. Patients who have undergone previous cardiac surgery
•6. Aged less than 69 years, either sex
•7. Written informed consent

•1. Marfan syndrome
•2. Reither's syndrome
•3. Rheumatoid arthritis
•4. Aged less than 5 years or greater than 69 years
•5. Inability to consent
•6. Other known disease potentially shortening life expectancy to less than 15 years
•7. When completeness of follow-up is judged unlikely by the investigators

发起方

Royal Brompton and Harefield NHS Foundation Trust (UK)